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Acknowledgements The authors are grateful for the support of NIH, to Lisa Howerton for her administrative support, and to the study participants and their families of the Mayo Pharmacogenomics Research Network-Antidepressant Pharmacogenomics Medication Study (PGRN-AMPS)

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This activation significantly increased the Bcl-2-associated X protein (Bax)/B-cell lymphoma 2 (Bcl-2) ratio and cysteine-aspartate protease 3 (Caspase-3) expression, inhibited GPX4 and quinone oxidoreductase 1 (NQO1) expression, increased MDA levels, and promoted apoptosis, ferroptosis, and lipid peroxidation in NSC-34 cells